Diversification of polyketide structures via synthase engineering
نویسندگان
چکیده
منابع مشابه
Genetic analysis of polyketide synthase and peptide synthase genes of cyanobacteria as a mining tool for new pharmaceutical compounds
Cyanobacteria are considered a promising source for new pharmaceutical lead compounds and a large number of chemically diverse and bioactive metabolites have been obtained from cyanobacteria. Despite of several worldwide studies on prevalence of NRPSs and PKSs among the cyanobacteria, none of them included Iranian cyanobacteria of Kermanshah province. Therefore, the aim of this study was t...
متن کاملDetection and Relation of Polyketide Synthase (PKSs) Genes With Antimicrobial Activity in Terrestrial Cyanobacteria of Lavasan
Background and Aims: Cyanobacteria are considered as favorable source for new pharmaceutical compounds. To date, the majority of bioactive metabolites isolated from cyanobacteria are either polyketides (PKSs) or non-ribosomal peptides. Despite of several worldwide studies on prevalence of PKSs, none of them included the terrestrial cyanobacteria of the Lavasan. Therefore, this study aimed to de...
متن کاملComprehensive Analysis of Polyketide Synthase Families
Polyketides (PKs) are a class of natural products (secondary metabolites) from bacteria, fungi, and plants, including many clinically important drugs such as tetracycline, daunorubicin, erythromycin, rapamycin and lovastatin [1, 4]. They have a large diversity of biological activities and pharmacological properties such as antibiotic, anticancer, antifungal, antiparasitic, cytostatic, and immun...
متن کاملBioinformatical Analysis of the Sequences, Structures and Functions of Fungal Polyketide Synthase Product Template Domains
The product template (PT) domains, specifically in fungal non-reducing polyketide synthases (NR-PKSs), mediate the regioselective cyclization of polyketides dominating the final structures. However, up to date, the systematic knowledge about PT domains has been insufficient. In present study, the relationships between sequences, structures and functions of the PT domains were analyzed with 661 ...
متن کاملTowards Precision Engineering of Canonical Polyketide Synthase Domains: Recent Advances and Future Prospects.
Modular polyketide synthases (mPKSs) build functionalized polymeric chains, some of which have become blockbuster therapeutics. Organized into repeating clusters (modules) of independently-folding domains, these assembly-line-like megasynthases can be engineered by introducing non-native components. However, poor introduction points and incompatible domain combinations can cause both unintended...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: MedChemComm
سال: 2019
ISSN: 2040-2503,2040-2511
DOI: 10.1039/c9md00141g